# Influence of biopsychosocial factors on a functionally delayed ageing process

## TL;DR

This study explores how biopsychosocial factors influence bio-functional age and identifies key areas that can be improved to support healthy aging.

## Contribution

The study identifies 10 influenceable parameters within the bio-functional status model that could support healthy aging.

## Key findings

- Regression analysis identified 10 parameters that may be influenceable to support healthy aging.
- Key factors include low social stress, high social integration, and good mental and cognitive status.
- Age and sex were found to influence bio-functional age and its index.

## Abstract

Increasing life expectancy and rising populations create new challenges for science, economy, politics, society and each individual. The bio-functional status (BFS) as a theoretical model incorporates the International Classification of Functioning (ICF) and the concept of active and healthy ageing (AHA). This study addresses the question of which the strengths and resources have the greatest positive impact on bio-functional age (BFA) and might be influencable.

A monocenter, cross-sectional, observational, non-interventional trial was performed from 2012 to 2014 at Inselspital Bern to evaluate the BFS, a complex, generic, non-invasive, sex- and age-validated assessment tool. A standardized battery of assessments was performed on 464 females and 166 males, aged 18 to 65 years (n = 630). We aimed to statistically identify BFS items that might be influenceable to support healthy ageing and vitality.

341 participants of the original cohort were included. After carrying out regression analysis, 10 parameters (T = 8.992; p < 0.001) remained as possible variables that can be influenced (R2 = 0.758). Of those identified parameters, one can be assigned to subcategory I of BFS (pulse performance index), two to II (tapping frequency part I and II), two to III (strategy building and verbal reaction time) and three to IV [sense of coherence, social potency, complaint questionnaire (BFB total)]. Age and sex, nevertheless, have an influence on the BFA and the BFA-Index.

The most promising approach to support vitality, is to support low social stress, high social integration, a good sense of coherence and maintaining a good mental and cognitive status.

The online version contains supplementary material available at 10.1007/s00404-024-07885-5.