# Delayed visceral malperfusion caused by kinking of a four-branched integrated frozen elephant trunk graft

**Authors:** Takuya Matsushiro, Tomoki Tamura, Nobuyuki Inoue, Tadashi Kitamura

PMC · DOI: 10.1093/icvts/ivaf052 · Interdisciplinary Cardiovascular and Thoracic Surgery · 2025-03-01

## TL;DR

A four-branched integrated frozen elephant trunk graft caused delayed complications due to kinking, leading to organ failure and limb ischemia, which were later corrected with a minimally invasive procedure.

## Contribution

Reports a novel complication of graft kinking with a newly available four-branched integrated frozen elephant trunk device.

## Key findings

- Postoperative graft kinking led to acute liver failure and kidney injury.
- Lower limb ischemia was also observed and corrected with thoracic endovascular aortic repair.
- The case highlights potential risks of the new four-branched graft design.

## Abstract

An integrated frozen elephant trunk with a four-branched vascular graft may shorten the circulatory arrest time during open distal anastomosis. We report a case of acute type A aortic dissection where postoperative graft kinking led to acute liver failure, kidney injury and lower limb ischaemia corrected by thoracic endovascular aortic repair.

In January 2023, the Frozenix 4 Branched (Japan Lifeline Co., Ltd, Tokyo, Japan) became commercially available.

## Linked entities

- **Diseases:** acute liver failure (MONDO:0019542)

## Full-text entities

- **Diseases:** visceral malperfusion (MESH:D007418), kidney injury (MESH:D007674), ischaemia (MESH:D007511), aortic dissection (MESH:D000784), acute liver failure (MESH:D017114)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11890289/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11890289/full.md

## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC11890289/full.md

---
Source: https://tomesphere.com/paper/PMC11890289