# Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone

## TL;DR

This study creates growth charts for Brazilian girls with Turner syndrome who did not use growth hormone or oxandrolone, to help monitor growth and treatment effects.

## Contribution

The study provides new growth charts for Turner syndrome girls in Brazil without GH or oxandrolone treatment.

## Key findings

- The mean height of TS patients at 20 years was 145.6 cm, below the target height of 157.8 cm.
- Height, weight, and BMI charts were developed for TS girls aged 2 to 20 years.
- The study used 3,160 height and 2,918 weight measurements from 259 TS patients.

## Abstract

The development of specific growth charts for Turner Syndrome (TS) promotes adequate assessment of growth and weight gain, and earlier diagnosis of comorbidities, and may help to analyze the effectiveness of treatments to promote growth and puberty. The aim of this study was to construct a growth chart with the largest possible series of patients with a cytogenetic diagnosis of TS from a Brazilian reference center.

This is a longitudinal study, with 259 cases of TS born between 1957 and 2014 and followed between 1975 and 2019, without the use of GH or oxandrolone. 3,160 height measurements and 2,918 wt measurements were used, with subsequent calculation of the Body Mass Index (BMI). For data analysis, the “GAMLSS” package of the “R” software was used.

The mean target height was 157.8 cm (standard deviation 5.2; median 160.4 cm). The mean height of patients with TS at 20 years of age was 145.6 cm (standard deviation 5.9; median 146.7 cm). Height, weight, and BMI by age graphs were developed for TS girls between 2 and 20 years.

These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth.