# Late-Onset Urticarial and Erythema Multiforme-Like Eruption Following SARS-CoV-2 Infection

**Authors:** Barbara S Suening, Molly E Boyko, Alicia J Starr, M. Holly Glover

PMC · DOI: 10.7759/cureus.78547 · Cureus · 2025-02-05

## TL;DR

This paper reports a case of a skin rash appearing five weeks after a SARS-CoV-2 infection, highlighting late-onset dermatological complications.

## Contribution

The study presents a unique case of late-onset urticarial and erythema multiforme-like eruption following SARS-CoV-2 infection.

## Key findings

- A patient developed a rapidly progressive urticarial dermatosis five weeks after SARS-CoV-2 infection.
- The eruption showed features of both urticaria and erythema multiforme.
- Histologic patterns suggest late-onset skin complications from SARS-CoV-2 beyond the acute phase.

## Abstract

Although SARS-CoV-2 primarily targets the upper respiratory system, its evolving clinical profile has revealed a diverse range of manifestations across multiple organ systems. Emerging evidence increasingly highlights various skin manifestations associated with the virus. This report details the case of a patient who developed a rapidly progressive urticarial dermatosis, characterized by both urticarial and erythema multiforme-like features, five weeks after a SARS-CoV-2 infection. Our objective is to underscore the histologic patterns of late-onset skin eruptions related to SARS-CoV-2, focusing on dermatological complications that can arise beyond the acute phase of the infection.

## Linked entities

- **Diseases:** erythema multiforme (MONDO:0006545)

## Full-text entities

- **Diseases:** Urticarial and Erythema Multiforme (MESH:D004892), skin eruptions (MESH:D012871), SARS-CoV-2 Infection (MESH:D000086382), infection (MESH:D007239)
- **Species:** Homo sapiens (human, species) [taxon 9606], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11887517/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC11887517/full.md

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Source: https://tomesphere.com/paper/PMC11887517