# Clinical features and prognosis of Pseudomonas aeruginosa infection in patients with hematologic malignancies

## TL;DR

This study examines the clinical features and risk factors for Pseudomonas aeruginosa infection in patients with blood cancers, finding that longer hospital stays and antibiotic use increase the risk of drug-resistant infections.

## Contribution

Identifies independent risk factors for CRPA infection and highlights the high mortality associated with bloodstream infections in hematologic malignancy patients.

## Key findings

- Longer hospital stays (>50 days), antibiotic exposure, and prior chemotherapy (>2 times) are independent risk factors for CRPA infection.
- CRPA-infected patients had a 28.1% 30-day mortality rate compared to 12.8% in CSPA-infected patients.
- Bloodstream infections are the main cause of death in patients with CRPA infections.

## Abstract

探讨恶性血液病患者发生铜绿假单胞菌感染的临床特征及预后影响因素。

回顾性分析2019年1月1日至2021年12月31日期间在福建医科大学附属协和医院血液科住院的197例合并铜绿假单胞菌感染的恶性血液病患者的临床资料。根据对碳青霉烯类药物的敏感性分为敏感组（CSPA感染组）和耐药组（CRPA感染组），比较两组患者临床特征的差异，分析容易发生CRPA感染的危险因素及预后情况。

Logistic回归多因素分析显示住院天数>50 d（P＝0.010，OR＝3.581，95％CI 1.356～9.457）、抗生素暴露史（P＝0.008，OR＝4.394，95％CI 1.358～6.238）、感染前化疗次数>2次（P＝0.006，OR＝2.911，95％CI 1.358～6.238）为发生CRPA感染的独立危险因素。CSPA感染组和CRPA感染组30 d全因死亡率分别为12.8％（18/140）、28.1％（16/57）（P＝0.010）。Logistic回归多因素分析显示血流感染（P＝0.039，OR＝5.286，95％CI 1.091～25.621）是恶性血液病伴CRPA感染死亡的独立危险因素。

住院天数>50 d、抗生素暴露史、感染前化疗次数>2次为恶性血液病患者发生CRPA感染的独立风险因素。血液病患者CRPA感染后死亡率高，血流感染为其主要死亡原因。