# Improving the application of metagenomic next-generation sequencing for pathogen diagnosis in infections related to hematological diseases

## TL;DR

This paper discusses how metagenomic next-generation sequencing (mNGS) can improve diagnosing infections in patients with hematological diseases.

## Contribution

The paper reviews the current status and challenges of mNGS in diagnosing infections related to hematological diseases.

## Key findings

- mNGS offers high sensitivity and broad coverage for pathogen detection.
- Challenges remain in the clinical application of mNGS for hematological infections.
- Understanding mNGS's value and limitations can guide its appropriate use.

## Abstract

血液病患者易发感染，且感染相关死亡率较高，感染病原的准确诊断至关重要，但常规微生物检测难以满足临床需求，成为临床面临的重要难题。宏基因组二代测序（mNGS）因其高灵敏度、广覆盖及检测周期短的特点，已在感染性疾病诊断中获得广泛应用。本文聚焦mNGS技术在血液病患者感染病原诊断中的应用现状，分析其在临床中面临的挑战和未来发展趋势，旨在帮助临床医师深入认识该技术在血液病感染诊断中的价值及局限性，以实现合理应用。