# Aetiology of haemorrhagic cystitis: BK Polyomavirus and Adenovirus detection

## TL;DR

A 49-year-old woman with leukemia developed bladder bleeding caused by two viruses, BK polyomavirus and adenovirus, highlighting immune system weaknesses.

## Contribution

Identification of a rare adenovirus genotype 78 in a leukemia patient with haemorrhagic cystitis.

## Key findings

- High adenovirus load detected in urine during chemotherapy cycles.
- Rare HAdV-B2 genotype 78 identified, closely related to HAdV-11.
- Viral presence suggests immune system vulnerabilities in leukemia patients.

## Abstract

This case report details haemorrhagic cystitis in a 49-year-old female with chronic lymphocytic leukaemia (CLL), recurrent haematuria and detected BK polyomavirus (BKPyV) and adenovirus (HAdV) in urine. During chemotherapy cycles, quantitative polymerase chain reaction (PCR) assays found high HAdV load, similar to a HAdV-B2 genotype 78, a rare genotype that is closely related to HAdV-11.

Viral interactions reveal immune system vulnerabilities.