# Surgical Intervention Improves Long‐Term Survival in Stage IV Thymic Epithelial Tumors: Insights From a SEER Database Analysis

## TL;DR

Surgery improves survival for stage IV thymic tumors, according to a study using SEER data.

## Contribution

The study shows surgery is an independent predictor of better survival in stage IV thymic epithelial tumors.

## Key findings

- Surgery was associated with significantly improved 5-year cancer-specific and overall survival rates.
- Propensity score matching and IPTW confirmed the survival benefit of surgery in stage IV TET patients.
- Subgroup analyses showed surgery benefits patients with lymph node or distant metastasis.

## Abstract

This research evaluates how surgical intervention affects survival rates in individuals with stage IV thymic epithelial tumors (TET) based on data from the SEER database, offering essential information for clinical decision making.

The SEER database (2004–2020) provided data on stage IV TET patients, classified into surgical and non‐surgical groups. Analytical techniques, including propensity score matching (PSM) and inverse probability treatment weighting (IPTW), were employed. The primary and secondary outcomes evaluated were cancer‐specific survival (CSS) and overall survival (OS), respectively.

Of 634 patients (394 diagnosed with thymoma and 240 with thymic carcinoma), 335 underwent surgery, while 299 did not. In univariate analysis, those who had surgery demonstrated significantly improved CSS and OS, with 5‐year survival rates of 74.6% for CSS and 62.3% for OS, compared to 41.4% and 26.0%, respectively, in the non‐surgical group. Multivariate analysis identified surgery as an independent factor for better CSS and OS. After applying PSM with 194 patients in each group, surgery continued to be associated with significantly improved CSS (HR = 0.417, 95% CI: 0.297–0.587, p < 0.001) and OS (HR = 0.457, 95% CI: 0.350–0.596, p < 0.001). Inverse probability of treatment weighting (IPTW) analysis confirmed these findings, showing better CSS (HR = 0.361, 95% CI: 0.265–0.492, p < 0.001) and OS (HR = 0.423, 95% CI: 0.335–0.535, p < 0.001). Subgroup analyses underscored the survival benefit of surgery for patients with stage IV thymoma and thymic carcinoma, including those with lymph node or distant metastasis.

For stage IV thymic epithelial tumors, the inclusion of surgery in multimodal treatment can improve patient survival.

This study utilized SEER data (2004–2020) to evaluate the impact of surgical intervention on survival in patients with stage IV thymic epithelial tumors. Among 634 patients, surgical treatment was linked to significantly better cancer‐specific survival (CSS) and overall survival (OS) compared to non‐surgical treatment, with results confirmed through propensity score matching (PSM) and inverse probability of treatment weighting (IPTW).