# RETRACTION: TMEM107 Inhibits EMT and Invasion of NSCLC Through Regulating the Hedgehog Pathway

PMC · DOI: 10.1111/1759-7714.70032 · Thoracic Cancer · 2025-03-07

## TL;DR

This retracted paper claimed that TMEM107 inhibits cancer cell invasion in lung cancer by affecting a specific pathway.

## Contribution

The paper originally proposed a novel mechanism involving TMEM107 and the Hedgehog pathway in NSCLC.

## Key findings

- TMEM107 was reported to inhibit EMT and invasion in NSCLC cells.
- The Hedgehog pathway was suggested to mediate TMEM107's effects.
- Duplicated images in figures led to retraction of the study.

## Abstract

RETRACTION:

XuH.
, 
DunS.
, 
GaoY.
, 
MingJ.
, 
HuiL.
, and 
QiuX.
, “TMEM107 Inhibits EMT and Invasion of NSCLC Through Regulating the Hedgehog Pathway,” Thoracic Cancer
12, no. 1 (2021): 79–89, 10.1111/1759-7714.13715.33124203
PMC7779196

The above article, published online on 29 October 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor‐in‐Chief, Tateaki Naito; and John Wiley & Sons Australia, Ltd. The retraction has been agreed following concerns raised by a third party about duplicated images in Figures 3i and 4e. The authors acknowledge this error and note that Figure 4e inadvertently included images from the si‐TMEM07 and pNC groups of Figure 3i for the A549 cells. Therefore, the article must be retracted.

## Linked entities

- **Genes:** TMEM107 (transmembrane protein 107) [NCBI Gene 84314]
- **Diseases:** NSCLC (MONDO:0005233)

## Full-text entities

- **Genes:** TMEM107 (transmembrane protein 107) [NCBI Gene 84314] {aka GRVS638, JBTS29, MKS13, PRO1268}
- **Diseases:** Thoracic Cancer (MESH:D009369)
- **Cell lines:** A549 — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_0023)

## Full text

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Source: https://tomesphere.com/paper/PMC11885886