Achieving High‐Precision Attenuation Coefficient Measurement in Optical Coherence Tomography
Linda B. Neubrand, Xavier Attendu, Ton G. van Leeuwen
TL;DR
This paper confirms a mathematical model for measuring light absorption in tissues using OCT, achieving high precision in experiments with intralipid samples.
Contribution
The study validates the Cramer-Rao lower bound equation for OCT attenuation coefficients with high precision.
Findings
The Cramer-Rao lower bound equation was experimentally validated for OCT attenuation measurements.
A standard deviation below 0.01 mm−1 was achieved for intralipid samples using a 1310 nm OCT system.
A systematic framework was introduced to achieve high precision in OCT attenuation measurements.
Abstract
In this study, we aim to validate the analytical Cramer‐Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm−1 for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements. We aim to determine the attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system with an unprecedented standard deviation below 0.01 mm−1 for intralipid samples. Our experimental results validate the analytical Cramer‐Rao lower bound equation. Additionally, we present a systematic framework for achieving high precision in OCT measurements.
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Taxonomy
TopicsOptical Coherence Tomography Applications · Photoacoustic and Ultrasonic Imaging · Coronary Interventions and Diagnostics