Five-year overall and specific survival of breast cancer in great Cuiaba (MT), Brazil

TL;DR

This study examines five-year survival rates for breast cancer in women in Brazil, finding that education and marital status significantly affect survival.

Contribution

The study identifies socioeconomic factors like education and marital status as significant predictors of breast cancer survival in a specific Brazilian region.

Findings

Overall and cancer-specific five-year survival rates were not statistically different (78.0% and 81.0%, respectively).

Women with lower education and those without a partner had significantly poorer survival rates.

The study highlights the need for policies targeting women with lower survival rates based on socioeconomic factors.

Abstract

To analyze the overall and cancer-specific five-year survival rates for female breast cancer in Greater Cuiabá, Mato Grosso, Brazil.

A non-concurrent, population-based cohort study using the Population-Based Cancer Registry of Greater Cuiabá (Cuiabá and Varzea Grande), including women diagnosed with breast cancer from 2008 to 2013, followed through 2018 in the regional mortality database. The sample consisted of a total of 1,220 women. Five-year survival analysis was performed using Kaplan-Meier curves and the Cox proportional hazards regression model, computing hazard ratios for variable estimation. Survival curves were compared using the log-rank test (p<0.05). Probabilistic linkage technique by the RecLink III software and survival analysis were conducted using STATA software version 12.0.

There was no statistical difference between the overall (OS) and cancer-specific survival (SS) rates (OS 78.0%, 95%CI 75.6–80.2; SS 81.0%, 95%CI 78.7–83.2). Women with lower educational levels (OS=58.33%; SS=64.89%) and those without a partner (OS 64.81%; SS 70.41%) exhibited poorer survival.

This study demonstrates that educational level and marital status significantly impact both overall and cancer-specific survival rates for female breast cancer. There is a need to propose policies that address the profile of women with lower survival rates.

Analisar a sobrevida global e específica em cinco anos para o câncer de mama feminino na Grande Cuiabá, Mato Grosso, Brasil.

Coorte não concorrente, de base populacional, por meio do Registro de Câncer de Base Populacional da Grande Cuiabá (Cuiabá e Várzea Grande), com mulheres diagnosticadas com câncer de mama no período de 2008 a 2013, seguidas até 2018 no banco de mortalidade regional. A amostra foi composta do total de 1.220 mulheres. Para a análise da sobrevida de cinco anos foram utilizadas as curvas de Kaplan-Meier e o modelo de regressão de riscos proporcionais de Cox, computando-se os hazard ratios para a estimativa das variáveis. Compararam-se as curvas por meio do teste log-rank (p<0,05). O linkage probabilístico foi realizado por meio do software Link Plus 2.0, e a análise de sobrevida foi realizada pelo STATA versão 12.0.

Não houve diferença estatística entre as sobrevidas global (SG) e a específica (SE) (SG 78,0%, intervalo de confiança de 95% — IC95% 75,6–80,2; SE 81,0%, IC95% 78,7–83,2). Apresentaram pior sobrevida as mulheres com menor escolaridade (SG 58,33%; SE 64,89%) e sem parceiro (SG 64,81%; SE 70,41%).

Observa-se, assim, que a escolaridade e o estado civil afetaram as sobrevidas global e específica para o câncer de mama feminino. Faz-se necessário propor políticas que atendam ao perfil de mulheres com menor sobrevida.

Figures