Hypereosinophilic Syndrome in a Patient With Complex Pulmonary Hypertension and Sjogren’s Syndrome: A Case Report

TL;DR

A 73-year-old man with pulmonary hypertension and asthma was diagnosed with hypereosinophilic syndrome and successfully treated with steroids and mepolizumab.

Contribution

This case report highlights the rare coexistence of hypereosinophilic syndrome with pulmonary hypertension and Sjogren’s syndrome.

Findings

The patient exhibited persistent eosinophilia consistent with hypereosinophilic syndrome.

Steroids and mepolizumab effectively managed the condition after excluding other differential diagnoses.

The case underscores the importance of considering hypereosinophilic syndrome in patients with complex pulmonary hypertension.

Abstract

We describe the case of a 73-year-old man who had been followed up by our clinic for pulmonary hypertension and asthma. He was later hospitalized and found to have significant and persistent eosinophilia compatible with hypereosinophilic syndrome. Various other conditions such as drug reaction with eosinophilia and systemic symptoms (DRESS), malignancy, and eosinophilic granulomatosis with polyangiitis (EGPA) were considered but largely excluded after further investigation. He responded well to steroids and was transitioned to mepolizumab for long-term control.

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