# Surgical treatment of subependymal giant cell astrocytoma in patients with tuberous sclerosis complex—an institutional experience and results

## TL;DR

This study examines the outcomes of surgically removing brain tumors in children with a genetic condition called tuberous sclerosis complex.

## Contribution

The paper provides a retrospective analysis of SEGA surgery outcomes in TSC patients, emphasizing safety and lack of cognitive impact.

## Key findings

- Surgery for SEGA in TSC patients had low complication rates and no mortality.
- There was no significant impact on cognitive function or epilepsy severity after surgery.
- Three out of 11 patients required repeated surgeries during follow-up.

## Abstract

Subependymal giant cell astrocytomas (SEGA) are present in patients with tuberous sclerosis complex (TSC), occasionally requiring surgical removal. The study aimed to analyze the results from our series of children undergoing surgery for SEGA.

We retrospectively identified children with TSC undergoing resection of SEGA at Oslo University Hospital between 1982 and 2016. Patient charts, radiological images, epilepsy, and neuropsychological reports were reviewed.

Out of 208 patients with TSC, 18 (9%) underwent resection of SEGA. Due to missing data, we could only analyze results from 14 surgeries in 11 children (median age 6 years, range 0–19; male/female ratio 2.7:1). The tumours were bilateral in four (36%) patients. The tumour diameter was a median of 19 mm (10–104 mm). The surgical approach was transcortical in eight (57%) and transcallosal in six surgeries (43%). Gross total resection was achieved in 12 (86%) of surgeries. There was no mortality or major morbidity related to surgery except for one case of chronic subdural hematoma, but out of two patients with ventriculoperitoneal shunts, one developed shunt infection, and both experienced shunt failures during the follow-up. During the follow-up (median 11 years, range 1–21), three patients (27%) underwent repeated surgery. We could not document any significant impact of the surgery on patients’ cognitive functioning or the grade of epilepsy.

Resection of SEGA in children with TSC was associated with a low complication rate. We could not document any impact of surgery on patients’ cognitive functioning or grade of epilepsy. However, the neuropsychological data were limited in most cases. Neuropsychological assessment should be performed before the surgery and be a part of follow-up after surgery.