The association between neighborhood environment, prenatal exposure to alcohol and tobacco, and structural brain development

TL;DR

This study explores how neighborhood environment and prenatal exposure to alcohol or tobacco affect brain development in children.

Contribution

The study reveals how neighborhood environment interacts differently with prenatal tobacco exposure in influencing brain volume.

Findings

High residential area deprivation was associated with smaller right hippocampal volume.

Prenatal tobacco exposure was linked to smaller volumes in several brain regions.

Neighborhood environment effects on brain volume were not significant in children with prenatal tobacco exposure.

Abstract

Prenatal alcohol and tobacco exposure affects child brain development. Less is known about how neighborhood environment (built, institutional, and social) may be associated with structural brain development and whether prenatal exposure to alcohol or tobacco may modify this relationship. The current study aimed to examine whether neighborhood environment is associated with brain volume at age 9–11, and whether prenatal exposure to alcohol or tobacco modifies this relationship. Baseline data from Adolescent Brain and Cognitive Development (ABCD) study was analyzed (N = 7,887). Neighborhood environment was characterized by 10 variables from the linked external dataset. Prenatal alcohol and tobacco exposures were dichotomized based on the developmental history questionnaire. Bilateral volumes of three regions of interests (hippocampal, parahippocampal, and entorhinal) were examined as outcomes. High residential area deprivation was associated with smaller right hippocampal volume. Prenatal alcohol exposure was associated with larger volume in left parahippocampal and hippocampal regions, while prenatal tobacco exposure was associated with smaller volumes in bilateral parahippocampal, right entorhinal, and right hippocampal regions. In children without prenatal tobacco exposure, high residential area deprivation was associated with smaller right hippocampal volumes. In contrast, neighborhood environment was not significantly associated with brain volumes in children with prenatal tobacco exposure. In summary, neighborhood environment plays a role in child brain development. This relationship may differ by prenatal tobacco exposure. Future studies on prenatal tobacco exposure may need to consider how postnatal neighborhood environment interacts with the teratogenic effect.

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