# Turner Syndrome and Gender Incongruence: Considerations for Gender Affirming Hormonal Therapy

## TL;DR

This paper discusses a case of a transgender male with Turner syndrome who successfully underwent masculinizing hormone therapy.

## Contribution

The paper presents a rare case of a transgender male with Turner syndrome undergoing and thriving on testosterone therapy.

## Key findings

- An adolescent with Turner syndrome mosaicism successfully transitioned using testosterone therapy.
- The case demonstrates the feasibility of gender-affirming care in a rarely studied population.
- The patient is thriving as a young adult transgender male following treatment.

## Abstract

Estrogen and growth hormone have been well established in the management of patients with Turner syndrome (TS) to improve linear growth, body composition, lipid profile, and bone mineral density. The use of testosterone therapy, however, has not been well studied in patients with TS. Furthermore, there is only one other known case report of an adult patient with TS seeking masculinizing therapy. We present an adolescent with mosaicism 45X/46XX who successfully underwent masculinizing therapy and is thriving as a young adult transgender male. This case highlights the benefits of gender affirming care despite the challenges of treatment in a population not previously described.