Neurological Manifestations Associated With Hypomagnesemia Due to Proton-Pump Inhibitors: A Case Series

TL;DR

This case series examines neurological symptoms in elderly men caused by low magnesium levels from long-term use of proton-pump inhibitors.

Contribution

The study highlights reversible neurological effects linked to hypomagnesemia due to prolonged pantoprazole use.

Findings

Hypomagnesemia and hypocalcemia were associated with neurological symptoms in elderly patients.

Long-term proton-pump inhibitor use was identified as a cause of hypomagnesemia.

Neurological syndromes were found to be reversible after addressing magnesium deficiency.

Abstract

We discuss a case series that explores the presentation and diagnostic challenges of three elderly male patients with hypomagnesemia. This series highlights the association between hypomagnesemia and hypocalcemia, both of which contribute to neurological symptoms. Proton-pump inhibitors, when taken for a long duration, are known to cause hypomagnesemia. This series also emphasizes the reversible neurological syndromes in patients with hypomagnesemia due to prolonged pantoprazole intake.