Bioinformatics Analysis Suggests That SE_1780 Protein From Staphylococcus Epidermidis May Be a Member of the Fph Family of Lipases

TL;DR

This paper suggests that a protein from Staphylococcus epidermidis, SE_1780, is a lipase belonging to the Fph family based on bioinformatics analysis.

Contribution

The novelty is identifying SE_1780 as a potential Fph family lipase with a predicted catalytic triad.

Findings

SE_1780 is proposed to be a lipase with an α/β hydrolase fold.

The catalytic triad Ser 144, Asp 235, and His 269 is predicted for SE_1780.

Lipase FphD shows significant sequence identity to SE_1780.

Abstract

The Protein Data Bank entry for protein SE_1780 from
Staphylococcus epidermidis
lists the function as unknown. We leveraged the framework outlined in the Biochemistry Authentic Scientific Inquiry Laboratory and used bioinformatics tools to ascertain the function of the protein. Based on our analysis, we posit that SE_1780 is a lipase of the α/β hydrolase family with a proposed active site catalytic triad composed of Ser 144, Asp 235, and His 269. Further we identified the lipase FphD as having significant sequence identity to protein SE_1780 and suggest that the protein is a member of the Fph family of lipases from
S. epidermidis
.

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