# Single-center observational analysis of a pharmacist-driven antibiotic time-out targeting antipseudomonal drugs

**Authors:** Carina Diaz, Alice Margulis Landayan, Lorenzo Porras, Sonia Samsundar, Jorge Murillo, Timothy P. Gauthier

PMC · DOI: 10.1017/ash.2025.6 · Antimicrobial Stewardship & Healthcare Epidemiology : ASHE · 2025-02-17

## TL;DR

A pharmacist-led review of antibiotic use at a hospital reduced antipseudomonal antibiotic use by 5%, potentially avoiding 1,800 days of therapy annually.

## Contribution

Implementation of a pharmacist-driven antibiotic time-out targeting antipseudomonal drugs in a community hospital.

## Key findings

- A 5% reduction in targeted antipseudomonal antibiotic use was observed.
- The reduction extrapolates to approximately 1,800 avoided days of therapy annually.

## Abstract

This study found that implementation of a pharmacist-driven antipseudomonal antibiotic time-out at a 450-bed community hospital led to a 5% reduction in the use of targeted antipseudomonal antibiotics (P = .12), which may be clinically meaningful as it extrapolates to approximately 1,800 avoided days of therapy annually.

## Full-text entities

- **Diseases:** C. difficile infection (MESH:D003015), genitourinary tract infection (MESH:C564424), intra-abdominal infection (MESH:D059413), nosocomial infections (MESH:D003428), pulmonary infection (MESH:D012141), infectious diseases (MESH:D003141), infection (MESH:D007239), allergy (MESH:D004342), skin and soft tissue infection (MESH:D018461)
- **Chemicals:** aztreonam (MESH:D001398), ciprofloxacin (MESH:D002939), Cefepime (MESH:D000077723), levofloxacin (MESH:D064704), piperacillin-tazobactam (MESH:D000077725)
- **Species:** Homo sapiens (human, species) [taxon 9606], Pseudomonas aeruginosa (species) [taxon 287]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11869067/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11869067/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC11869067/full.md

---
Source: https://tomesphere.com/paper/PMC11869067