# Efficacy of the PanCareFollowUp eHealth Lifestyle Intervention for Survivors of Childhood, Adolescent and Young Adult Cancer

## TL;DR

An online lifestyle coaching program helps childhood, adolescent, and young adult cancer survivors improve their health and maintain goals over time.

## Contribution

The study evaluates the efficacy of a 4-month eHealth lifestyle intervention for CAYA cancer survivors.

## Key findings

- 68% of goals were achieved after 4 months of coaching, and 76% were sustained after 4 months of follow-up.
- Significant improvements were observed in BMI, diet, and physical activity over time.
- Participants with lower BMI and fewer depressive feelings were more likely to achieve and sustain goals.

## Abstract

A healthy lifestyle may prevent or mitigate late effects in childhood, adolescent and young adult (CAYA) cancer survivors. To support survivors in adopting healthier behaviours, the PanCareFollowUp (PCFU) Lifestyle intervention was developed, encompassing 4 months of online lifestyle coaching aimed at achieving a personal lifestyle goal. The aims of this study were to (1) determine the efficacy of this intervention on lifestyle outcomes over time and (2) identify predictors for goal achievement.

Fifty‐eight survivors were enrolled. Outcomes were assessed at baseline (T0), after 4 months of coaching (T1) and after 4 months of follow‐up (T2). The primary outcome included the percentage of survivors successful in achieving and sustaining their goal, whereas secondary outcomes included differences in body mass index (BMI), diet and physical activity. To evaluate the adjusted, longitudinal effects on secondary outcomes, linear mixed models were estimated. Predictors for goal achievement were identified through logistic regression analysis.

At T1 and T2, 68% and 76% of goals were achieved or sustained, respectively. Mean differences between T2 and T0 showed significant improvements in BMI (−0.5 kg/m2), diet (−0.6 points) and physical activity (+7.7 h/week). Estimation of multivariable models also showed positive effects. Participants with a lower BMI and fewer depressive feelings at baseline were more likely to achieve and/or sustain their goals at T2.

Findings suggest that the PCFU Lifestyle intervention supports survivors in making lifestyle changes. Results can be used to inform a subsequent randomised intervention study and integrate lifestyle coaching into care.

Trial Registration: International Clinical Trial Registry Platform (ICTRP) number: NL8932 (ICTRP Search Portal [who. int]). Registered on 29 September 2020

Within the European PanCareFollowUp project, an eHealth lifestyle intervention was developed to guide survivors of childhood, adolescent and young adult cancer in adopting healthier behaviours. Results from this efficacy analysis are positive and can be used for further study and implementation.