# Caenorhabditis Intervention Testing Program: all-trans retinoic acid-related compounds tamibarotene and bakuchiol do not extend lifespan in Caenorhabditis nematodes

## TL;DR

This study tested two compounds related to all-trans retinoic acid and found they did not extend the lifespan of Caenorhabditis nematodes.

## Contribution

The study shows that atRA-related compounds may not universally extend lifespan in nematodes.

## Key findings

- Tamibarotene and bakuchiol did not significantly increase lifespan in Caenorhabditis species.
- Bakuchiol was toxic at higher doses.
- The results emphasize the specificity of all-trans retinoic acid's effects on longevity.

## Abstract

The
Caenorhabditis
Intervention Testing Program recently characterized the longevity-promoting effects of the vitamin A derivative all-trans retinoic acid (atRA). Here, we test two atRA-related compounds, tamibarotene and bakuchiol, for longevity effects in three strains of
Caenorhabditis
species. Both tamibarotene, a potent RAR agonist, and bakuchiol, a meroterpene derived from
Psoralea corylifolia
, showed no significant increase in lifespan across a dosage range of six concentrations. Additionally, bakuchiol was broadly toxic at higher doses. These findings highlight the specificity of atRA's longevity effects and suggest that compounds related to atRA may not universally promote lifespan extension.