# The M.3.2 mutation in Drosophila melanogaster mapped as a novel allele of ​​ tout-velu

## TL;DR

A new mutation in fruit flies causes eye abnormalities and is linked to a known gene called tout-velu.

## Contribution

The M.3.2 mutation is identified as a novel allele of the tout-velu gene in Drosophila.

## Key findings

- M.3.2 causes cuticle expansion in the eye area and smaller eye size in Drosophila.
- Genetic and molecular mapping confirmed the mutation is in the tout-velu (ttv) gene.
- The mutation was identified through a screen for cell division and patterning defects.

## Abstract

In
Drosophila melanogaster
genetic screens are often used to identify genes associated with different biological processes. Here, we have utilized the Flp/FRT system to generate mitotic clones within the developing eye. These clones were screened for mutations that disrupt cell division, organ patterning, and cell growth. One such mutation from this screen, mutant M.3.2, resulted in an expansion of the cuticle within the area normally covered by ommatidium as well as an overall smaller eye size. Genetic and molecular mapping revealed this mutation to be in the gene, t
out-velu
(
ttv
).