# Uterine carcinosarcoma with heterologous osseous elements: a case report of an extremely rare clinical occurrence with literature review

**Authors:** Hiba A. Al Dallal, Taylor H. Jacobs, Cody L. Bergman, Siddharth Narayanan, Arshi Kaur, Samer Z. Al-Quran, Harpreet Kaur Chopra

PMC · DOI: 10.3389/fonc.2025.1505504 · 2025-02-14

## TL;DR

A rare case of uterine carcinosarcoma with bone-like elements in a young woman is reported, highlighting unusual clinical features and the need for thorough evaluation.

## Contribution

This case report presents an exceptionally rare occurrence of uterine carcinosarcoma with osseous elements in a young patient.

## Key findings

- A 31-year-old female was diagnosed with uterine carcinosarcoma containing heterologous osseous elements.
- The patient underwent successful surgical resection and remains in remission during follow-up.
- The case emphasizes the diverse clinical manifestations of uterine carcinosarcoma and the importance of comprehensive evaluation.

## Abstract

Carcinosarcoma is a rare and aggressive malignant neoplasm that predominantly affects elderly postmenopausal women and can involve various gynecologic organs. It is characterized by the presence of both malignant epithelial and sarcomatous components. While most uterine carcinosarcomas (UCS) are homologous (sarcomatous component consisting of elements native to the uterus), heterologous components are less common and may vary in composition. Rare heterologous elements can include lipomatous (liposarcoma) or osseous elements (osteosarcoma). We present an unusual case of a 31-year-old female with UCS exhibiting osseous heterologous elements. The patient underwent successful surgical resection and remains in remission during follow-up. This case is notable for its rarity, as highlighted by the uncommon age of the patient and the presence of rare heterologous elements in the UCS. Furthermore, it provides new insights into the diverse presentations of UCS and underscores the importance of comprehensive evaluation in understanding its clinical manifestations.

## Linked entities

- **Diseases:** uterine carcinosarcoma (MONDO:0006485), osteosarcoma (MONDO:0002623), liposarcoma (MONDO:0003585)

## Full-text entities

- **Diseases:** neoplasm (MESH:D009369), osteosarcoma (MESH:D012516), lipomatous (MESH:D008080), Carcinosarcoma (MESH:D002296)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11867948/full.md

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Source: https://tomesphere.com/paper/PMC11867948