Four-Step Synthesis of 3-Allyl-2-(allyloxy)-5-bromoaniline from 2-Allylphenol
Enrique B. Aparicio, Stephen R. Isbel, Alejandro Bugarin
TL;DR
This paper describes a four-step method to synthesize a specific aniline compound from a commercially available starting material.
Contribution
A novel four-step synthesis of 3-allyl-2-(allyloxy)-5-bromoaniline from 2-allylphenol is presented.
Findings
The synthesis involves nitration, selective bromination, allylation, and nitro group reduction.
The method uses commercially available starting materials.
The protocol is efficient and suitable for producing the target compound.
Abstract
This communication reports a four-step protocol to produce 3-allyl-2-(allyloxy)-5-bromoaniline 5 from commercially available 2-allylphenol. The synthetic steps used were nitration, selective bromination, allylation, and reduction of the nitro group.
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Taxonomy
TopicsAmmonia Synthesis and Nitrogen Reduction · Nanomaterials for catalytic reactions · Asymmetric Hydrogenation and Catalysis