Increased antinuclear (anti-Sm) antibodies in infertile patients with peritoneal endometriosis
Renata Fogaça Borges, Vanessa Krebs Genro, Carlos Augusto Bastos de Souza, Tatiana Ferreira Michelon, Isabel Meneghetti Coimbra, João Sabino Lahorgue da Cunha-Filho
TL;DR
This study found higher levels of anti-Sm antibodies in infertile women with mild endometriosis compared to fertile women.
Contribution
The study identifies a novel association between anti-Sm antibodies and minimal/mild endometriosis in infertile patients.
Findings
Anti-Sm antibody levels were higher in infertile women with endometriosis.
No significant differences were found for anti-RNP and anti-SS-A antibodies between the groups.
The study links endometriosis to increased autoimmunity as indicated by anti-Sm antibodies.
Abstract
The aim of this study is to evaluate the intensity of five antibodies against extractable nuclear antigens (ENA: RNP, ScL-70, SS-B, SS-A, and Sm) in infertile patients with endometriosis. We investigated infertile women with minimal/mild endometriosis (n=43) and fertile women (n=46). The intensity of immunoreactions was also similar for anti-RNP and anti-SS-A antibodies. However, the intensity of immunoreactivity for anti-Sm antibodies was higher in the endometriosis group. Patients with minimal/mild endometriosis have higher levels of anti-Sm autoantibodies.
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Taxonomy
TopicsEndometriosis Research and Treatment · Coagulation, Bradykinin, Polyphosphates, and Angioedema