# Liquid Nitrogen as a Novel Treatment for Gingival Depigmentation: A Case Report

**Authors:** Kamala K A, S Sankethguddad

PMC · DOI: 10.7759/cureus.78099 · Cureus · 2025-01-27

## TL;DR

This case report shows that liquid nitrogen can effectively and safely remove dark pigmentation from the gums, improving the appearance of a gummy smile.

## Contribution

The paper introduces liquid nitrogen cryosurgery as a novel and effective method for gingival depigmentation.

## Key findings

- Liquid nitrogen cryosurgery successfully depigmented the gingiva in a case study.
- No complications were observed during the six-month follow-up period.
- The technique provided high patient satisfaction and cosmetic results.

## Abstract

Gingiva is an important part of a smile, and it is considered the most frequently pigmented tissue in the oral cavity. Although gingival pigmentation is physiologic in most cases, it is one of the common causes of esthetic concerns in patients with gummy smiles. Hence, the demand for cosmetic therapy of gingival melanin pigmentation has become common. Numerous procedures have been suggested to treat this problem, such as gingivectomy, free gingival grafts, cryosurgery, electrosurgery, laser therapy, etc. Here we report a case of gingival hyperpigmentation using liquid nitrogen cryosurgery. The six-month follow-up examination confirmed effective depigmentation with no complications. This simple technique proves to be an excellent choice for managing gingival pigmentation, offering both pleasing cosmetic results and high patient satisfaction.

## Linked entities

- **Chemicals:** liquid nitrogen (PubChem CID 947)

## Full-text entities

- **Diseases:** pigmentation (MESH:D010859), gingival hyperpigmentation (MESH:D017495), Gingival Depigmentation (MESH:D005891)
- **Chemicals:** Liquid (-), Nitrogen (MESH:D009584), melanin (MESH:D008543)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11865256/full.md

## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC11865256/full.md

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Source: https://tomesphere.com/paper/PMC11865256