# Truncated tau disrupts autophagy and endolysosomal systems

**Authors:** Saskia J. Pollack, Diane P. Hanger, Wendy Noble, Maria Jimenez-Sanchez

PMC · DOI: 10.1080/27694127.2024.2409563 · Autophagy Reports · 2024-10-08

## Full-text entities

- **Genes:** cathepsin D [NCBI Gene 100766628], MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}, EEA1 [NCBI Gene 100758601], LAMP2 [NCBI Gene 100689316], mTOR [NCBI Gene 100755421], TFEB [NCBI Gene 100769893]
- **Diseases:** Endosomal abnormalities (MESH:D000014), Tauopathies (MESH:D024801), cognitive and motor deficits (MESH:D003072), AD (MESH:D000544), neurodegenerative disease (MESH:D019636)
- **Chemicals:** BODIPY (MESH:C095489), lipid (MESH:D008055), CHO (-), LysoTracker (MESH:C493330)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090], Cricetulus griseus (Chinese hamster, species) [taxon 10029]
- **Cell lines:** FL- — Homo sapiens (Human), Oligodendroglioma, Cancer cell line (CVCL_B1D4), Chinese hamster — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_0212), CHO — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_0213)

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## References

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Source: https://tomesphere.com/paper/PMC11864699