# LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?

## TL;DR

This paper suggests that LC3-associated phagocytosis may help sort proteins for degradation by grouping them in specific areas of cell membranes.

## Contribution

The paper proposes a novel mechanistic role for LC3-associated phagocytosis as a sorting mechanism for membrane proteins.

## Key findings

- LAP may cluster proteins for degradation in discrete phagosomal membrane domains.
- The study suggests LAP integrates phagocytosis and autophagy mechanisms.
- Findings hint at LAP's role in immune signaling and antigen presentation.

## Abstract

The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood. Based on observations from our recent study, we propose that LAP might serve as a sorting mechanism to cluster proteins destined for degradation into discrete domains of the phagosomal membrane.