# Simple accessible clemastine fumarate analogues as effective antileishmanials

## TL;DR

Researchers developed simpler versions of a drug called clemastine fumarate that are easier to make and work well against leishmaniasis.

## Contribution

The study introduces simpler N-linked analogues of clemastine fumarate with improved accessibility and selectivity.

## Key findings

- N-linked analogues are easier to synthesize than clemastine fumarate.
- The analogues show higher selectivity and comparable efficacy in treating Leishmania amazonensis infection in mice.

## Abstract

Current therapeutic options for leishmaniasis are severely limited, highlighting an urgent need to develop more effective and less toxic drugs to combat a major global public health challenge. Clemastine fumarate displays good levels of antileishmanial efficacy, but further optimisation is challenged by its difficult synthesis. Here, we demonstrate that simple N-linked analogues are easier to access, can exhibit higher selectivity and show comparable efficacy in a mouse model of Leishmania amazonensis infection.

N-linked analogues of clemastine fumarate afford simpler, more accessible, more selective antileishmanials.