# Neurobiological markers of early stressful events in psychosis

## TL;DR

This study explores how genetic risk and childhood stress contribute to mental illness and aging in schizophrenia and bipolar disorder.

## Contribution

The study combines genetic and environmental factors to assess their combined impact on mental illness risk and clinical outcomes.

## Key findings

- Polygenic risk and childhood adversity may jointly increase mental illness risk beyond individual effects.
- The study examines how these factors influence clinical features and aging processes in psychosis.
- New systematic reviews and original data are used to support these findings.

## Abstract

New data from the MRC funded project “Integrating psychological models with biological pathways in psychosis” will be presented. The overall objective of this project is to use both environmental and genetic data to understand the biological pathways in patients with schizophrenia and bipolar disorders. Specifically, to find out if polygenic risk and childhood adverse events increase the relative risk of mental illness above that of its individual case-control explained variance, and secondly, the effect of both polygenic risk and childhood adverse events on clinical characteristics and ageing processes. Both data from new unpublished systematic reviews and original data will be presented.

None Declared