# Temporal changes in corticosteroid dose during ibrutinib treatment in patients with cGVHD and pulmonary involvement

## TL;DR

This study examines how ibrutinib affects corticosteroid use and lung function in patients with chronic graft-versus-host disease and lung involvement.

## Contribution

The study provides insights into ibrutinib's potential to reduce corticosteroid doses without worsening lung function in cGVHD patients.

## Key findings

- Five out of seven patients with lung involvement experienced a decrease in corticosteroid dose.
- One patient's lung function improved to over 80% predicted FEV1.
- Symptom scores remained stable in patients with lung involvement.

## Abstract

The GVH3001 study assessed the efficacy and safety of ibrutinib in Japanese patients with steroid-dependent or -refractory chronic graft-versus-host disease (cGVHD). However, the effects of ibrutinib on lung function and reduction in corticosteroid dose, which is a measurable factor associated with improved quality of life, could not be adequately assessed in patients who initially presented with lung involvement. This post hoc analysis aimed to evaluate temporal changes in daily corticosteroid dose, as well as effectiveness outcomes based on lung function and symptom burden (percent predicted forced expiratory volume in 1 s [%FEV1] and Lee cGVHD Symptom Scale lung subscale score, respectively) in the subgroup of patients with cGVHD who had lung involvement at baseline. Seven of the 19 patients in the GVH3001 study had lung involvement at baseline. The daily corticosteroid dose for cGVHD decreased in five of these patients, and %FEV1 remained relatively stable in two patients but increased to > 80% in one patient. Lee cGVHD Symptom Scale scores were relatively stable throughout the study in patients with lung involvement. Ibrutinib may allow corticosteroid dose reduction without worsening lung function or increasing symptom burden in previously treated patients with cGVHD and associated lung involvement.

The online version contains supplementary material available at 10.1007/s12185-024-03882-1.