Mechanistic Insights into the Therapeutic Efficacy of Qi Ling Gui Fu Prescription in Broiler Ascites Syndrome: A Network Pharmacology and Experimental Study
Jie Kang, Ruiqiang Deng, Keyao Wang, Huimin Wang, Yufeng Han, Zhibian Duan
TL;DR
This study investigates how Qi Ling Gui Fu Prescription treats broiler ascites syndrome by targeting vascular smooth muscle and the MAPK signaling pathway.
Contribution
The study provides new mechanistic insights into QLGFP's therapeutic effects on broiler ascites syndrome via network pharmacology and experimental validation.
Findings
QLGFP's active compounds inhibit phenotypic transformation of vascular smooth muscle in broiler ascites syndrome.
The MAPK signaling pathway is a key target of QLGFP in treating broiler ascites syndrome.
QLGFP reduces ascites cardiac index and suppresses MAPK pathway proteins in experimental models.
Abstract
In this research, we explored the active components and therapeutic mechanisms of QLGFP for treating broiler AS using a network pharmacology approach. A total of 267 active compounds were isolated, of which the main active components were Dihydrokaranone, Tanshiquinone B, Neotanshinone C, etc. Bioinformatics analysis and an animal experiment indicated that the MAPK signalling pathway is the key target for QLGFP and their active compounds to improve the AS broilers by inhibiting phenotypic transformation of vascular smooth muscle. Our findings provide a scientific basis for the clinical efficacy of QLGFP in the treatment of broiler AS and a solid foundation for further elucidation of the active components and mechanism of action of QLGFP in the treatment of broiler AS. This study delves into the therapeutic potential of Qi Ling Gui Fu Prescription (QLGFP) in broiler ascites syndrome…
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Taxonomy
TopicsTraditional Chinese Medicine Analysis · Genomics, phytochemicals, and oxidative stress · Physiological and biochemical adaptations