Involvement of CB1R and CB2R Ligands in Sleep Disorders and Addictive Behaviors in the Last 25 Years
Marcel Pérez-Morales, Rodolfo Espinoza-Abad, Fabio García-García
TL;DR
This review explores how cannabinoids affect sleep and addiction over 25 years, highlighting their potential benefits and risks.
Contribution
The paper provides a comprehensive review of CB1R and CB2R ligand effects on sleep and addiction mechanisms from 2000 to 2024.
Findings
Cannabinoids may improve sleep in animal models and humans but require clinical validation.
Chronic marijuana use could reduce dopamine responsivity and increase negative emotions.
Pharmacodynamics of cannabinoids influence sleep-wake cycles and addictive behaviors.
Abstract
Over the last three decades, the decriminalization and legalization of therapeutic and recreational marijuana consumption have increased. Consequently, the availability of marijuana-based products associated with its therapeutic use has increased. These developments have stimulated research on cannabinoids involving a wide range of animal models and clinical trials. Also, it is reported that cannabinoids promote sleep in animal models and naïve human participants, and they seem to improve insomnia and sleep apnea in patients. However, evidence from rigorous clinical trials is needed. In addition, among several physiological processes, cannabinoid receptors modulate dopamine synthesis and release. In this regard, the side effects of marijuana and marijuana derivatives must not be ignored. The chronic consumption of marijuana could reduce dopamine responsivity, increase negative…
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Taxonomy
TopicsCannabis and Cannabinoid Research · Sleep and Wakefulness Research · Neurotransmitter Receptor Influence on Behavior