# A Case of Infantile Reversible Cytochrome C Oxidase Deficiency Myopathy in Taiwan: A 4-Year Follow-Up

## TL;DR

This paper reports a rare case of infantile reversible mitochondrial myopathy in a child from Taiwan, highlighting its unique non-progressive nature.

## Contribution

The study contributes a detailed clinical follow-up of a rare, reversible mitochondrial disease with spontaneous improvement.

## Key findings

- The patient showed generalized muscle weakness and hypotonia at a very early age.
- Symptoms improved spontaneously over time, distinguishing it from typical progressive mitochondrial myopathies.
- The case provides insights into the clinical course of this rare and reversible condition.

## Abstract

Infantile reversible cytochrome c oxidase (COX) deficiency myopathy is a mitochondrial rare disease with onset age of first day to three months with symptoms of generalized muscle weakness and severe hypotonia. Despite its initial serious conditions, the symptoms may improve spontaneously later in their life, with the so-called “benign” myopathy accordingly. This benign mitochondrial myopathy might be improved in their later life, which is different from most mitochondrial myopathies with progression by age. Therefore, we depicted the rare case of her clinical course during our medical practice, anticipating to provide more information of this rare disease.