# Effects of Heyndrickxia coagulans on Waterborne Copper Toxicity

## TL;DR

This study shows that Heyndrickxia coagulans may help reduce kidney damage caused by copper toxicity in rats.

## Contribution

The novel contribution is demonstrating the protective effects of H. coagulans on copper-induced toxicity, particularly in renal health.

## Key findings

- Rats receiving H. coagulans showed improved renal function and antioxidant enzyme activity.
- Lipid profiles and histological markers were significantly better in the H. coagulans group.
- Liver function remained largely unaffected by H. coagulans treatment.

## Abstract

Copper contamination in coastal water environments poses a significant health risk, and traditional treatments for copper intoxication include gastric lavage, chelation, and hemodialysis. Recent research suggests that probiotics may help mitigate heavy metal toxicity by promoting biosorption in the intestinal tract. To explore this potential, we investigated the protective effects of Heyndrickxia coagulans (H. coagulans) against copper-induced toxicity in rats. After eight weeks of exposure, rats receiving both copper and H. coagulans exhibited significant improvements in renal function, lipid profiles, antioxidant enzyme activity, and histological markers compared to the copper-only group. However, liver function remained largely unchanged, suggesting a more pronounced protective effect on renal health. These findings highlight the potential of H. coagulans as a supportive intervention for mitigating the adverse effects of copper intoxication.