# Serum Creatinine Level in Relation to Intraluminal Thrombus and Abdominal Aortic Aneurysm Size

## TL;DR

This study found no link between kidney function (measured by creatinine) and the size of abdominal aortic aneurysms or the amount of blood clot in the aorta.

## Contribution

The novel contribution is the investigation of serum creatinine's relationship with intraluminal thrombus and AAA size in a cross-sectional study.

## Key findings

- No association was found between creatinine levels and intraluminal thrombus or AAA volume.
- ILT volume was positively associated with AAA volume, regardless of creatinine levels.
- Adjusting for AAA size and comorbidities showed no significant differences in ILT volume between normal and elevated creatinine groups.

## Abstract

Objectives: Abdominal aortic aneurysm (AAA) diameter is the primary predictor of AAA rupture. However, smaller aneurysms do rupture, and other parameters are required for a more nuanced risk stratification. Reduced renal function is associated with increased cardiovascular risk and thrombosis, but the impact of renal function on ILT and AAA size remains unknown. This study aimed to investigate the association between creatinine level and volume of ILT and AAA. Methods: In a cross-sectional study, 184 patients with AAA under ultrasound surveillance were included. ILT volume and thickness, and AAA volume and diameter, were measured using three-dimensional contrast-enhanced ultrasound. ILT and AAA measures were compared with creatinine levels. Results: No associations were found between creatinine level and ILT or AAA volume (p = 0.18 and p = 0.41). There were no differences in ILT volume between patients with normal and elevated creatinine levels, when adjusting for AAA size and comorbidities (p = 0.06 and p = 0.54). A positive association was found between ILT volume and AAA volume (p < 0.001). Creatinine level did not influence this association (p = 0.06). Conclusions: In this study, creatinine level did not seem associated with ILT or AAA volume. Longitudinal studies are required to elucidate associations between renal function, clinical outcomes, and ILT and AAA development.