# Identification of Alterations in the Expression of Genes Related to the Implant Failure in Spanish Patients with Down Syndrome and Periodontal Disease

## TL;DR

This study identifies genetic markers linked to dental implant failure in Spanish Down syndrome patients with periodontal disease.

## Contribution

The study discovers specific genes associated with implant failure in Down syndrome patients, offering new insights for personalized treatment.

## Key findings

- Genes like MMP15, MMP17, and S100B show altered expression in patients with implant failure.
- These genetic changes are strongly linked to poor osseointegration and implant loss.
- The findings highlight the role of inflammation and bone metabolism genes in implant failure.

## Abstract

Background: Individuals with Down syndrome exhibit a higher prevalence of periodontal disease, which can lead to implant loss. This study aims to identify genetic markers associated with implant loss in these patients, providing insight into potential predictive and therapeutic approaches. Methods: A systematic analysis was conducted, including both clinical and genetic data from Down syndrome patients with a history of dental implants. Genetic profiling was performed using Transcriptome Analysis Console (TAC version 4.0 Applied BiosystemsTM, Thermo Fisher Scientific, Waltham, MA, USA), focusing on genes previously implicated in periodontal disease and bone metabolism. Statistical analysis identified correlations between genetic variants and implant survival rates. Results: The analysis revealed statistically significant alterations in several genes related to inflammation and bone remodeling. Key findings included alterations in the expression of the genes MMP15, MMP17, S100B, GHR, DNAH6, and ZCCHC14 in patients with implant failure. These genetic markers were strongly correlated with compromised osseointegration and implant loss. These findings underline the role of genetic predisposition in the failure of dental implants among individuals with Down syndrome. Conclusions: Genetic markers, particularly those involved in inflammation and bone metabolism, play a critical role in implant loss among Down syndrome patients with periodontal disease. Recognizing these markers can aid in early diagnosis and personalized treatment strategies, potentially improving implant success rates.