# The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs

## TL;DR

This paper reviews how ferroptosis, a type of cell death, affects infections and tissue damage in pigs and how nutrition can regulate it.

## Contribution

The paper provides a comprehensive review of ferroptosis in pigs and its nutritional regulation, offering new insights for disease treatment.

## Key findings

- Ferroptosis is linked to tissue damage and diseases in pigs.
- Nutritional strategies targeting ferroptosis show promise for treating infections and injuries.
- The role of ferroptosis in pigs is multifaceted and understudied.

## Abstract

Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by iron overload and excessive lipid peroxidation. To date, numerous studies in human and mouse models have shown that ferroptosis is closely related to tissue damage and various diseases. In recent years, ferroptosis has also been found to play an indispensable and multifaceted role in infection and tissue injury in pigs, and nutritional regulation strategies targeting ferroptosis show great potential. In this review, we summarize the research progress of ferroptosis and its role in infection and tissue injury in pigs. Furthermore, we discuss the existing evidence on ferroptosis regulation by nutrients, aiming to provide valuable insights for future investigation into ferroptosis in pigs and offer a novel perspective for the treatment of infection and injury in pigs.