# Role of Perinatal Stem Cell Secretome as Potential Therapy for Muscular Dystrophies

## TL;DR

This review explores how perinatal stem cell secretome could help treat muscular dystrophies by targeting inflammation.

## Contribution

The paper reviews the potential of perinatal stem cell secretome as a novel therapy for modulating inflammation in muscular dystrophies.

## Key findings

- Chronic inflammation in muscular dystrophies significantly affects disease progression.
- Perinatal stem cell secretome shows promise in modulating immune responses and tissue repair.
- Literature supports the use of perinatal stem cells to target MD inflammation.

## Abstract

Inflammation mechanisms play a critical role in muscle homeostasis, and in Muscular Dystrophies (MDs), the myofiber damage triggers chronic inflammation which significantly controls the disease progression. Immunomodulatory strategies able to target inflammatory pathways and mitigate the immune-mediated damage in MDs may provide new therapeutic options. Owing to its capacity of influencing the immune response and enhancing tissue repair, stem cells’ secretome has been proposed as an adjunct or standalone treatment for MDs. In this review study, we discuss the challenging points related to the inflammation condition characterizing MD pathology and provide a concise summary of the literature supporting the potential of perinatal stem cells in targeting and modulating the MD inflammation.