# Case report of a seminal vesicle schwannoma involving prostate and bladder: diagnostic pathway and management

**Authors:** Paolo Pietro Suraci, Yazan Al Salhi, Giuseppe Candita, Andrea Fuschi, Silvio Scalzo, Onofrio Antonio Rera, Fabio Maria Valenzi, Alice Antonioni, Manfredi Bruno Sequi, Damiano Graziani, Giorgio Martino, Giovanni Di Gregorio, Filippo Gianfrancesco, Luca Erra, Kostika Lako, Alessandro Zucchi, Giorgio Bozzini, Paola Capodiferro, Vincenzo Petrozza, Antonio Carbone, Antonio Luigi Pastore

PMC · DOI: 10.1093/jscr/rjaf094 · 2025-02-25

## TL;DR

A rare case of a benign nerve tumor in the seminal vesicle, prostate, and bladder is reported, with diagnosis confirmed through biopsy and surgery.

## Contribution

This case report adds to the limited literature on seminal vesicle schwannomas and highlights the diagnostic and management approach.

## Key findings

- A 65-year-old man presented with lower urinary tract symptoms and multiple nodular lesions.
- Histopathology confirmed schwannoma in the prostate, seminal vesicle, and bladder wall.
- Prostate biopsy and trans-urethral resection aided diagnosis and lesion removal.

## Abstract

Seminal vesicle neoplasms are extremely rare. Schwannoma is a benign tumor of the peripheral nerve sheath composed of Schwann cells. Most of these tumors are silent and become symptomatic with compression of adjacent organs and nerves. We present a case of a 65-year-old man with a history of predominant storage lower urinary tract symptoms. Prostate-specific antigen was within normal ranges, and imaging documented a nodular lesion in the prostate, one in the left seminal vesicle and another one adjacent to the right bladder wall. We successfully performed a prostate biopsy and a trans-urethral resection of the bladder to excise and typify the lesion. Histopathology investigation revealed the final diagnosis of schwannoma.

## Linked entities

- **Diseases:** schwannoma (MONDO:0002546)

## Full-text entities

- **Genes:** KLK3 (kallikrein related peptidase 3) [NCBI Gene 354] {aka APS, KLK2A1, PSA, hK3}
- **Diseases:** nodular lesion in the prostate (MESH:D011469), Schwannoma (MESH:D009442), benign tumor (MESH:D009369), Seminal vesicle neoplasms (MESH:C537244), urinary tract symptoms (MESH:D014570)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11851478/full.md

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Source: https://tomesphere.com/paper/PMC11851478