Myocardial DYRK1B Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing

TL;DR

This study shows that higher levels of DYRK1B in heart tissue are linked to poor heart function and sleep-disordered breathing in patients with heart disease.

Contribution

The study identifies DYRK1B as a potential molecular target in heart failure and sleep-disordered breathing in humans.

Findings

Increased DYRK1B expression is associated with impaired cardiac function and sleep-disordered breathing.

Left ventricular ejection fraction and sleep-disordered breathing are significant predictors of DYRK1B expression.

DYRK1B may serve as a promising therapeutic target for heart failure and sleep-disordered breathing.

Abstract

Heart failure and cardiovascular disease represent a significant burden on healthcare systems worldwide. Recent evidence associates an increased expression of the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with an impaired cardiac function in mice. However, there remains a paucity of data on myocardial DYRK1B expression in patients with cardiovascular disease in the context of other comorbidities. In our study, we examined DYRK1B mRNA expression in human right atrial appendage biopsies from 159 patients undergoing elective coronary artery bypass surgery. Each patient was tested for sleep-disordered breathing the night prior to surgery. In this large representative study cohort with cardiovascular high-risk patients, we found that an impaired cardiac function as well as sleep-disordered breathing (SDB), including various oxidative stress parameters, were associated with an increased myocardial DYRK1B expression. A multivariate regression analysis revealed left ventricular ejection fraction and the presence of SDB as significant predictors of the myocardial DYRK1B expression independent of other clinical covariates. Based on these findings, DYRK1B represents a promising molecular target in patients with heart failure and reduced ejection fraction as well in patients with sleep-disordered breathing.

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