# Low-Crosslinked Hyaluronic Acid Injections in the Superficial Fat Layer for Facial Rejuvenation in Chinese Patients: A Retrospective Clinical Study

## TL;DR

This study shows that low-crosslinked hyaluronic acid injections in the facial fat layer effectively rejuvenate the skin in Chinese patients with high satisfaction and minimal side effects.

## Contribution

Demonstrates the efficacy and safety of low-crosslinked hyaluronic acid for facial rejuvenation in Chinese patients using a specific injection technique.

## Key findings

- Significant improvements in wrinkles, pore size, and pigmentation were observed at one and three months post-treatment.
- 93.3% patient satisfaction was reported at three months with minimal adverse reactions.
- Mild discomfort and bruising were the only reported side effects, resolving quickly.

## Abstract

Objective

To evaluate the clinical efficacy of low-crosslinked hyaluronic acid (HA) injections in the superficial fat layer for facial rejuvenation in Chinese patients.

Methods

A total of 30 patients were treated between July 2023 and October 2024, with three sessions of low-crosslinked HA injections spaced one month apart. The injections were administered using the fanning technique into the superficial fat layer. Patients were followed up at one month and three months post-treatment. Skin improvements were assessed using smart skin analysis equipment, while overall aesthetic improvement was evaluated using the Global Aesthetic Improvement Scale (GAIS). Patient pain levels, satisfaction, and adverse reactions were also recorded.

Results

Significant improvements in facial wrinkles, pore size, and pigmentation were observed at one and three months post-treatment, as measured by skin analysis equipment, compared to baseline. GAIS scores confirmed facial rejuvenation in all patients. Patient satisfaction was 100% at one month and 93.3% at three months. Mild discomfort was reported by 90% of patients, with an average pain score of 3.40 ± 1.55, resolving within 24 hours. Two patients experienced mild bruising, which resolved within a week. No other adverse reactions were noted.

Conclusion

Low-crosslinked HA injection in the superficial fat layer is an effective and safe method for facial rejuvenation, offering high patient satisfaction. No serious adverse events were reported during the follow-up period.