# A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11)

## TL;DR

A new fusion gene involving ETV6 and a noncoding RNA is linked to a severe form of leukemia with a poor prognosis.

## Contribution

Identifies a novel ETV6 fusion partner, AC010198.2, associated with del(12)(p13p11) in post-MPN AML.

## Key findings

- ETV6::AC010198.2 fusion is linked to del(12)(p13p11) in post-MPN AML.
- The fusion gene is associated with poor prognosis and disease deterioration.
- This fusion may be a key event in MPN transformation to AML.

## Abstract

The gene ETV6 has been confirmed to be a genetic susceptibility gene for thrombocytopenia and leukemia. Here, we report a long-chain noncoding RNA AC010198.2 as a novel fusion partner of ETV6, showing a karyotype of del(12)(p13p11), with poor prognosis in a post-MPN AML that has never been reported, which may be an vital initial event in the transformation of MPN to AML and deterioration of disease.