# Purity control of simulated moving bed based on advanced fuzzy II controller

**Authors:** Chao-Fan Xie, Ting Lin, Hong Zhang, Dr Satya Veerendra Arigela, Mazyar Ghadiri Nejad, Mazyar Ghadiri Nejad

PMC · DOI: 10.1371/journal.pone.0314545 · PLOS One · 2025-02-24

## TL;DR

This paper introduces an advanced fuzzy II controller to improve the purity control and stability of simulated moving bed chromatographic separation.

## Contribution

The novel contribution is the development of an advanced fuzzy II-type controller that enhances extraction accuracy and stability in SMB processes.

## Key findings

- The advanced fuzzy II controller improved material B extraction accuracy by 0.7% and material A by 0.1% compared to the I-type controller.
- Compared to traditional fuzzy controllers, material B accuracy improved by 0.35% with stable material A performance.
- The II-type controller showed 0.6% better precision stability and maintained stability during parameter fluctuations unlike traditional controllers.

## Abstract

Simulated Moving Bed (SMB) is the optimal technology for chromatographic separation, but its process is complex and sensitive to numerous parameters that affect separation performance, making it difficult to control. In recent years, fuzzy controllers have been widely applied in industry due to their simplicity, robustness, and ease of implementation. However, traditional fuzzy controllers used in industry do not consider the error acceleration term. In steady-state conditions, error acceleration is typically slightly less than the target value. Introducing the acceleration term, albeit non-fuzzy, in a proactive fuzzy I-type controller often leads to an increase in steady-state values. The study shows that, compared to the advanced fuzzy I-type controller, the extraction accuracy for material B improved by an average of 0.7%, while the accuracy for material A increased by 0.1%. Compared to traditional fuzzy controllers, the extraction accuracy for material B improved by an average of 0.35%, while the accuracy for material A remained relatively stable. In terms of stability analysis concerning variations in moving bed parameters, the advanced fuzzy II-type controller exhibited greater stability than the I-type, with an average precision stability improvement of 0.6%. Traditional fuzzy controllers demonstrated pathological characteristics during fluctuations in the switching time parameter, whereas the advanced fuzzy II type controller-maintained stability.

## Full-text entities

- **Diseases:** SMB (MESH:D003668)
- **Chemicals:** PONE-D-24-28958Purity (-), carbohydrates (MESH:D002241)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC11849874/full.md

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Source: https://tomesphere.com/paper/PMC11849874