# Spindle Cell Lipoma in the Lower Lip: A Report of a Rare Case in Plastic Surgery

**Authors:** Isao Nagata, Toshihito Mitsui, Yuki Matsuoka, Masakatsu Hihara, Natsuko Kakudo

PMC · DOI: 10.7759/cureus.77956 · Cureus · 2025-01-25

## TL;DR

This paper reports a rare case of spindle cell lipoma in the lower lip, highlighting the importance of histopathology for accurate diagnosis.

## Contribution

The novelty lies in documenting a rare occurrence of SCL in the lip, a location with sparse adipose tissue.

## Key findings

- Surgical excision and histopathology confirmed SCL in a submucosal lower lip mass.
- CD34-positive/S100-negative cells were identified, aiding in diagnosis.
- Differential diagnosis with liposarcoma is emphasized as critical and challenging.

## Abstract

Spindle cell lipoma (SCL) is a rare subtype of lipoma. SCL is commonly reported in subcutaneous tissues of the neck, shoulders, and back, but its occurrence in the lip, where adipose tissue is sparse, is rare. We present a case of SCL in a 53-year-old woman referred to our plastic surgery department with a chief complaint of a submucosal mass in the right lower lip. Magnetic resonance imaging (MRI) revealed a mass in the submucosal tissue of the lower lip. Surgical excision was performed through a lip incision. Histopathological examination confirmed the diagnosis of SCL with the presence of CD34-positive/S100-negative cells. Differential diagnosis between SCL and liposarcoma is crucial and challenging based on clinical or imaging findings, emphasizing the importance of histopathological examination.

## Linked entities

- **Proteins:** CD34 (CD34 molecule), S100A1 (S100 calcium binding protein A1)
- **Diseases:** spindle cell lipoma (MONDO:0000962), liposarcoma (MONDO:0003585)

## Full-text entities

- **Genes:** CD34 (CD34 molecule) [NCBI Gene 947], S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}
- **Diseases:** lipoma (MESH:D008067), liposarcoma (MESH:D008080), mass (MESH:C536030), SCL (MESH:D002277)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11849262/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC11849262/full.md

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Source: https://tomesphere.com/paper/PMC11849262