# Intestinal Flora Dysregulation and Lung Cancer: Mechanism Analysis and Clinical Application

## TL;DR

This paper explores how gut bacteria influence lung cancer development and treatment, highlighting potential clinical applications.

## Contribution

The paper systematically analyzes the mechanisms linking gut flora to lung cancer and discusses clinical application potential.

## Key findings

- Gut microbiota regulate immunity and metabolism, impacting lung cancer progression.
- Modulating gut flora may improve lung cancer treatment outcomes.
- Gut-lung axis mechanisms offer new therapeutic strategies for lung cancer.

## Abstract

肺癌作为全球致死性最高的恶性肿瘤，每年新增病例数以百万计。尽管手术、靶向治疗和免疫治疗技术快速发展，极大改善了患者的生存状况，然而其总体5年生存率仍较低。近年来，研究发现肠道菌群在维持宿主健康中起到至关重要的作用，并通过多种机制与肺癌的发生发展密切相关。本文从肠道菌群的免疫调控、代谢调节及其在肺癌治疗中的应用等方面，对肠道菌群在肺癌中的作用机制进行了系统分析，展望了其在临床应用中的潜力。