# Erasmus Syndrome: Diffuse Systemic Sclerosis With Silicosis

## TL;DR

A 30-year-old man developed a rare condition called Erasmus syndrome after occupational exposure to silica and coal dust, leading to silicosis and autoimmune disease.

## Contribution

This case report highlights the rare association between accelerated silicosis and diffuse systemic sclerosis, emphasizing the role of occupational silica exposure.

## Key findings

- The patient developed accelerated silicosis-associated diffuse systemic sclerosis within a decade of occupational exposure.
- The case underscores the importance of monitoring and regulating silica exposure to prevent autoimmune diseases.
- Early intervention and protective measures are crucial in preventing such occupational-related autoimmune conditions.

## Abstract

This report describes the case of a 30-year-old man with a history of prolonged occupational exposure to silica and coal dust leading to the development of Erasmus syndrome, a rare condition of silicosis associated with autoimmune disease, i.e., systemic sclerosis, in a short period. The patient was a laborer in the mining and construction industry, and he presented within a decade of occupational exposure with progressive dyspnea, chronic cough, skin thickening, inflammatory polyarthritis, and Raynaud's phenomenon. Clinical, radiological, and serological tests revealed "accelerated silicosis-associated diffuse systemic sclerosis". Treatment involved stoppage of occupational exposure to silica and symptomatic and immunosuppressive therapy.

The case highlights the significance of occupational silica exposure in the development of autoimmune diseases and stresses the need for early intervention, the initiation of protective measures, and the strict monitoring of permissible silica exposure by regulatory authorities.