# Multiple Eruptive Dermatofibromas: A Case Series and Review of Diagnostic Challenges and Systemic Associations

## TL;DR

This paper presents three cases of a rare skin condition called multiple eruptive dermatofibromas and discusses its diagnosis and possible links to immune and genetic factors.

## Contribution

The study contributes new clinical insights and emphasizes the importance of combined diagnostic methods for MEDF.

## Key findings

- Three female patients with MEDF showed distinct clinical features and systemic associations.
- Histopathological findings confirmed MEDF diagnoses and highlighted the need for integrated diagnostic approaches.
- The study suggests immune dysregulation and genetic factors may play a role in MEDF development.

## Abstract

Multiple eruptive dermatofibromas (MEDF) is a rare dermatological condition characterized by the sudden appearance of multiple benign skin lesions, often associated with systemic or autoimmune conditions. This case series describes three female patients with MEDF, highlighting their distinct clinical features and systemic associations. Diagnoses were confirmed through consistent histopathological findings, demonstrating the importance of integrating clinical, dermoscopic, and histopathological evaluations in diagnosing MEDF. The differential diagnosis included other dermatological conditions with overlapping features, which were excluded based on clinical and pathological findings. This report emphasizes the potential role of immune dysregulation and genetic predisposition in MEDF pathogenesis. It underscores the need for further research to understand its mechanisms better, improve diagnostic accuracy, and establish standardized management approaches.