# The morphological, clinical, and prognostic factors in the management of giant anterior communicating artery aneurysms: A systematic review of cases

## TL;DR

This paper reviews factors affecting the treatment of rare giant aneurysms in the anterior communicating artery, highlighting the best approaches for ruptured and unruptured cases.

## Contribution

The study provides a systematic review of clinical and morphological factors in managing giant AComm aneurysms, emphasizing treatment nuances.

## Key findings

- Direct clipping is the first-line treatment for ruptured giant AComm aneurysms.
- Surgical bypass and trapping are preferred for unruptured or asymptomatic cases.
- Endovascular/combined methods have limited data and are used in fewer cases.

## Abstract

Giant intracranial aneurysms (GIAs) of the anterior communicating artery (AComm) are rare and challenging to treat due to their distinct angioarchitecture.

To review demographic, morphological, clinical, and prognostic factors in the treatment of giant AComm aneurysms to inform decision-making.

Medline, Scopus, and Cochrane databases were searched for records examining cases diagnosed with giant AComm aneurysms. The study type, sample size, patient age, aneurysm site, aneurysm size, presenting complaints, and treatment modality were tabulated, and methodological quality was assessed. Additionally, two cases from our institution were included.

The data from 24 retrieved records, including 45 cases (60% treated with direct clipping/clip reconstruction, 20% with surgical bypass±trapping, and 16% with endovascular/combined methods) were obtained. The mean age was 52 years with an overall male preponderance (3:1). 73% presented with symptoms; mostly visual impairment/loss and subarachnoid hemorrhage. 82% had favorable outcomes (mRS 0–2). 56% had a mean maximum diameter between 25 and 30 mm. Cases treated by direct clipping/reconstruction were primarily ruptured, while cases treated by surgical bypass/trapping were unruptured or asymptomatic. Endovascular/combined methods were utilized for only few cases.

Immediate suspicion is warranted for visual impairment with headaches in adults or seizures in the elderly. Direct clipping is the first-line treatment for ruptured cases closely followed by surgical bypass and trapping for unruptured cases. There is limited data on endovascular/combined methods. Evidence from case reports/series should be interpreted with caution. Both inter-modality and intra-modality nuances exist.

•Giant intracranial aneurysms of the anterior communicating artery (AComm) are rare and challenging to treat.•They yield favorable outcomes and present with symptoms – often visual impairment, and subarachnoid hemorrhage.•They present with a mean maximum diameter between 25-30 mm and are mostly thrombosed and occasionally calcified/sclerosed.•Direct clipping is the first-line modality for ruptured cases followed by surgical bypass for unruptured/asymptomatic cases•There is limited data on endovascular/combined methods.•Individualized care is warranted and caution is advised when interpreting from evidence from case reports/series.

Giant intracranial aneurysms of the anterior communicating artery (AComm) are rare and challenging to treat.

They yield favorable outcomes and present with symptoms – often visual impairment, and subarachnoid hemorrhage.

They present with a mean maximum diameter between 25-30 mm and are mostly thrombosed and occasionally calcified/sclerosed.

Direct clipping is the first-line modality for ruptured cases followed by surgical bypass for unruptured/asymptomatic cases

There is limited data on endovascular/combined methods.

Individualized care is warranted and caution is advised when interpreting from evidence from case reports/series.