# Time to First Analgesic Administration in the Emergency Department for Adolescents/Young Adults With Sickle Cell Disease: A Retrospective Cross-Sectional Study

## TL;DR

This study examines how long it takes to give pain medicine to young sickle cell patients in the emergency department and finds that delays are common, which may lead to more hospital admissions.

## Contribution

The study evaluates guideline adherence and TFAA impact on ED disposition for SCD patients, revealing potential for improved care through faster analgesic administration.

## Key findings

- Most ED encounters were classified as ESI 3, with a mean TFAA of 108.9 minutes.
- Only 4.1% of encounters followed both NHLBI ESI and TFAA guidelines.
- Faster TFAA may reduce hospital admission rates for SCD patients.

## Abstract

Many adolescent and young adult (AYA) patients with sickle cell disease (SCD) visit the emergency department (ED) for vaso-occlusive crisis (VOC) pain management. Clinical guidelines from the National Heart, Lung, and Blood Institute (NHLBI) suggest that patients should receive an Emergency Severity Index (ESI) of 2 and analgesics within 60 minutes of registration. Despite guidelines, SCD patients experience treatment delays. Our objectives are to describe a Mid-Atlantic healthcare system's guideline adherence and examine the effect of time to first analgesic administration (TFAA) on ED disposition. A retrospective cross-sectional study of the electronic health record data set of ED SCD patient encounters from July 2016 to June 2017 was conducted. Descriptive statistics were run for patient characteristics. ED encounters that followed NHLBI guidelines were included in the data set. Independent t-tests were conducted to examine TFAA differences among patients admitted and not admitted. Majority of encounters were classified as ESI 3 (75.6%), and the mean TFAA was 108.9 minutes. Of ED encounters, 23.9% followed ESI guidelines, 21.5% followed TFAA guidelines, and 4.1% followed both NHLBI guidelines. There was a nearly significant difference in mean TFAA among patients discharged from the ED and admitted to the hospital, a mean difference of -24.5 minutes (t=-1.925; p=0.056). Despite existing ED guidelines, SCD patients experience delayed and variable care. Our results show faster TFAA could potentially decrease admission rates.