# Severe Thrombocytopenia in the Post-surgical Context and Administration of Factor VIIII (FVIII)/von Willebrand Factor (VWF) Concentrate in a Patient With von Willebrand Disease Type 2M

## TL;DR

This paper discusses a challenging case of severe low platelet count in a patient with von Willebrand disease after surgery, linked to treatment with a blood clotting factor.

## Contribution

The paper highlights a rare complication of thrombocytopenia possibly caused by FVIII/VWF concentrate administration in a post-surgical VWD patient.

## Key findings

- The patient's platelet count worsened following administrations of Wilate.
- The case suggests a potential direct relationship between Wilate and thrombocytopenia.
- Balancing hemorrhage prevention and thrombosis risk is critical in VWD management.

## Abstract

Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It can be associated with a life-threatening risk of excessive bleeding in surgical procedures, and may require prophylactic treatment with a combined factor VIIII (FVIII)/von Willebrand factor (VWF) concentrate. Management of these patients may be challenging when trying to achieve the balance between avoiding the risk of haemorrhage and causing a risk of thrombosis with the treatment. We present a complex case of severe thrombocytopenia in a post-surgical setting, in which the timeline suggests a direct relationship between the worsening of platelet count and wilate administrations.